反应详情

To a suspension of 5-amino-1-methyl-4-phenoxycarbonylaminopyrazole (153.8 g) in tetrahydrofuran (1 L) were added triethylamine (67 g) and triphenylmethyl chloride (185 g) at room temperature. The mixture was stirred for 6.5 hours. To the reaction mixture was added heptane (2.6 L) and the mixture was stirred for 1 hour. The precipitated solid was collected by filtration and washed with heptane-diisopropyl ether (1:1). The crude solid was suspended in water (3 L) and the suspension was stirred for 1 hour. The solid was collected by filtration and dried to give 1-methyl-4-phenoxycarbonylamino-5-triphenylmethylaminopyrazole (253.6 g).

1. stirringthe mixture was stirred for 1 hour
2. filtrationThe precipitated solid was collected by filtration
3. washwashed with heptane-diisopropyl ether (1:1)
4. stirringthe suspension was stirred for 1 hour
5. filtrationThe solid was collected by filtration
6. customdried