Potassium Carbonate → HCID 21395230, compound

HRID 461005Notes

Reaction equation

HRID 461005 reaction equation
[ClH:1].[CH2:2]([N:4]([CH2:8][CH3:9])[CH2:5][CH2:6][Cl:7])[CH3:3].[C:10]([NH:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-:26].[K+].[K+]>C(O)(C)C>[C:10]([NH:18][CH:19]1[CH2:24][CH2:23][N:22]([CH2:3][CH2:2][N:4]([CH2:8][CH3:9])[CH2:5][CH3:6])[CH2:21][CH2:20]1)(=[O:17])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1.[OH2:26].[ClH:7].[ClH:1].[ClH:7].[ClH:7]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 118120N-4-Piperidylbenzamide

Product 2

HCID 21395230HCID 21395230, compoundHCID 131710748HCID 131710748, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Equimolar amounts of 2-diethylaminoethyl chloride, hydrochloride and 4-benzamidopiperidine were stirred under reflux in isopropanol with 2.5 molar equivalents of anhydrous potassium carbonate for 18 hours. The hot suspension was filtered and the filtrate was treated with ethereal HCl to give the title compound as a dihydrochloride, hemihydrate, m.p. >220° (with decomp.)

Workup

  1. filtrationThe hot suspension was filtered
  2. additionthe filtrate was treated with ethereal HCl

Sources & evidence

ORD record
ord-cf130ce939d641f5b057effd84a5efbe
Source dataset
uspto-grants-1977_12
Patent number
US04061758

Reaction notes

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