p-Toluenesulfonic acid → HCID 22760595, compound

HRID 461106Notes

Reaction equation

HRID 461106 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([OH:27])[CH2:23][S:22][C:21](=[N:24][CH3:25])[N:20]2[CH3:26])=[CH:15][C:14]=1[S:28](=[O:31])(=[O:30])[NH2:29].C(OC(C)C)(C)C>C(O)C>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([OH:27])[CH2:23][S:22][C:21](=[N:24][CH3:25])[N:20]2[CH3:26])=[CH:15][C:14]=1[S:28](=[O:30])(=[O:31])[NH2:29].[CH3:11][C:1]1[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 7914Diisopropyl EtherHCID 721562-Chloro-5-(4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl)benzenesulfonamide

Product 1

HCID 22760595HCID 22760595, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g of p-toluene sulfonic acid was added to a suspension of 1.5 g of 4-(4-chloro-3-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol in 10 ml of ethanol. The clear solution was poured into 60 ml of diisopropyl ether and the oil so obtained was recrystallized by treating with diethyl ether. Colorless crystals were obtained which were decomposed from 94° C onwards.

Workup

  1. customthe oil so obtained
  2. customwas recrystallized
  3. additionby treating with diethyl ether
  4. customColorless crystals were obtained which
  5. customwere decomposed from 94° C

Sources & evidence

ORD record
ord-f813a076dfc64515b1a051fbc74c78de
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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