反应详情

Iodoethane (70 g) was added to a solution of diethyl 1,4-dihydroxy-2,3-naphthalenedicarboxylate (35 g) in ethanolic sodium ethoxide, prepared from sodium (7.6 g) and ethanol (250 ml), and the mixture was heated under reflux for 3 hours. After keeping overnight at room temperature, the mixture was poured onto ice-hydrochloric acid (500 ml). The oil was separated, washed with aqueous sodium bicarbonate and crystallised from ethanol to give diethyl 1,4-diethoxy-2,3-naphthalenedicarboxylate, (IV) m.p. 68°.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. additionthe mixture was poured onto ice-hydrochloric acid (500 ml)
4. customThe oil was separated
5. washwashed with aqueous sodium bicarbonate
6. customcrystallised from ethanol