HRID462265

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID31268

Pyrrolidine

C4H9N

结构：O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(Cl)CS[C@H]12

HCID70558958

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(N3CCCC3)CS[C@H]12

HCID70632343

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

溶剂HCID57417360

Sodium chloride; water

ClH2NaO

PROCEDURE

实验过程

To a solution of 0.988 g. (2 mmole) of p-nitrobenzyl 7-[2-(2-thienyl)acetamido]-3-chloro-3-cephem-4-carboxylate in 10 ml. of dry DMF maintained at ice-bath temperature were added 0.375 ml. (4.4 mmole) of pyrrolidine. The reaction mixture was allowed to stir for about one hour and the mixture was then diluted with brine and ethyl acetate. The ethyl acetate was washed with brine several times and dried over magnesium sulfate. Evaporation of the dried extract gave 845 mg. of product.

WORKUP

后处理

additionwere added 0.375 ml
washThe ethyl acetate was washed with brine several times
dry with materialdried over magnesium sulfate
customEvaporation of the dried
extractionextract
customgave 845 mg

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-452613959a274cb5a4a8c7451e558150
来源数据集: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04065618
来源说明: uspto-grants-1977_12

反应 SMILES

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:31](=[O:32])[N:12]2[C:13]([C:18]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=3)=[O:19])=[C:14](Cl)[CH2:15][S:16][C@H:11]12)=[O:8].CN(C=O)C.[NH:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1>[Cl-].[Na+].O.C(OCC)(=O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:31](=[O:32])[N:12]2[C:13]([C:18]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=3)=[O:19])=[C:14]([N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)[CH2:15][S:16][C@H:11]12)=[O:8]