反应详情

A suspension of 30 g of 1-methyl-2-nitroimidazole-5-methanol, 22 g of 4-aminophenol and 55 g of triphenylphosphane in 600 ml of anhydrous tetrahydrofuran was treated dropwise with vigorous stirring within 20 minutes with a solution of 42.5 g of diisopropyl azodicarboxylate in 300 ml of anhydrous tetrahydrofuran. The mixture was maintained at a temperature of 20°-24° C. by external cooling. After 2 hours, the clear solution obtained was evaporated under reduced pressure and the residue was boiled briefly with a mixture of 125 ml of methylene chloride and 125 ml of ethyl acetate to yield 24.4 g (52%) of crystalline α-(1-methyl-2-nitroimidazol-5-yl)-p-anisidine, m.p. 168°-170° C.

1. additionwas treated dropwise
2. temperatureThe mixture was maintained at a temperature of 20°-24° C. by external cooling
3. customthe clear solution obtained
4. customwas evaporated under reduced pressure
5. additionthe residue was boiled briefly with a mixture of 125 ml of methylene chloride and 125 ml of ethyl acetate