Chlorodifluoromethane → HCID 20185697, compound

HRID 463957Notes

Reaction equation

HRID 463957 reaction equation
[F:1][CH:2]([F:4])Cl.[NH2:5][C:6]1[N:11]=[C:10]([SH:12])[N:9]=[C:8]([O:13][CH3:14])[N:7]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[NH2:5][C:6]1[N:11]=[C:10]([S:12][CH:2]([F:4])[F:1])[N:9]=[C:8]([O:13][CH3:14])[N:7]=1

Participants

5

Reactant 3

HCID 6372ChlorodifluoromethaneHCID 11430Potassium CarbonateHCID 178494245HCID 178494245, compound

Product 1

HCID 20185697HCID 20185697, compoundYield 24.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

10.0 g of gaseous difluorochloromethane are passed into a suspension of 5.0 g of 2-amino-4-mercapto-6-methoxy-1,3,5-triazine and 4.8 g of potassium carbonate in 100 ml of dimethylformamide at a temperature of 70°-75° C. over a period of 90 minutes. The reaction mixture is evaporated, the residue is stirred with water and the solid precipitate is separated off to give 1.6 g of 2-amino-4-difluoromethylthio-6-methoxy-1,3,5-triazine of melting point 146°-150° C.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe solid precipitate is separated off

Sources & evidence

ORD record
ord-34f47f6b49a5439abd557f03bf2209de
Source dataset
uspto-grants-1985_10
Patent number
US04545811

Reaction notes

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