p-Bromochlorobenzene → HCID 14249972, compound

Temperature

100 °C

To a suspension of triphenyl phosphine (2.1 g, 8.0 mmole) in 300 ml of triethylamine and 30 ml of acetonitrile under nitrogen is added successively palladium (II) acetate (0.45 g, 2.0 mmole), 1-bromo-4-chlorobenzene (19.1 g, 110 mmole) and 3-buten-1-ol (7.21 g, 100 mmole) in a pressure tube. The tube is sealed and heated in an oil bath to 100° C. for 24 hr. The tube is opened under nitrogen, charged with additional palladium (II) acetate, resealed and heated 20 hr longer at 100°-120° C. The mixture is cooled, vented to nitrogen and partitioned between 300 ml of 2N hydrochloric acid and ether. The layers are separated and the aqueous layer is extracted with two additional volumes of ether. The combined ether extracts are washed with 2×100 ml portions of 2N hydrochloric acid and then dried over sodium sulfate. The filtered ether extract is concentrated under vacuum to give 12.7 g of crude product which is purified by chromatography on silica gel using toluene eluent. There is obtained 9.5 g of the title compound. Rf =0.77 (silica gel, toluene).

1. customThe tube is sealed
2. temperatureheated 20 hr longer at 100°-120° C
3. temperatureThe mixture is cooled
4. custompartitioned between 300 ml of 2N hydrochloric acid and ether
5. customThe layers are separated
6. extractionthe aqueous layer is extracted with two additional volumes of ether
7. washThe combined ether extracts are washed with 2×100 ml portions of 2N hydrochloric acid
8. dry with materialdried over sodium sulfate
9. extractionThe filtered ether extract
10. concentrationis concentrated under vacuum
11. customto give 12.7 g of crude product which
12. customis purified by chromatography on silica gel

ORD record

ord-77d486a5858d426ea1b7199dae512c12

Source dataset

uspto-grants-1985_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04545995