Sodium Iodide → [4-Benzhydryloxycarbonyl-7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-cephem-3-ylmethyl]triphenylphosphonium chloride

HRID 464219Notes

Reaction equation

HRID 464219 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7](=[N:38][O:39][CH2:40][CH3:41])[C:8]([NH:10][CH:11]2[C:36](=[O:37])[N:13]3[C:14]([C:20]([O:22][CH:23]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:21])=[C:15]([CH2:18][Cl:19])[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1.[C:42]1([P:48]([C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1.[I-].[Na+]>C(OCC)(=O)C>[Cl-:19].[CH:23]([O:22][C:20]([C:14]1[N:13]2[C:36](=[O:37])[CH:11]([NH:10][C:8](=[O:9])[C:7]([C:4]3[N:3]=[C:2]([NH2:1])[S:6][N:5]=3)=[N:38][O:39][CH2:40][CH3:41])[C@H:12]2[S:17][CH2:16][C:15]=1[CH2:18][P+:48]([C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)([C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)[C:55]1[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=1)=[O:21])([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 11776TriphenylphosphineHCID 131714229Benzhydryl 7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

Product 1

HCID 131714367[4-Benzhydryloxycarbonyl-7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-cephem-3-ylmethyl]triphenylphosphonium chlorideYield 59.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of benzhydryl 7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate (syn isomer) (36.7 g) in ethyl acetate (600 ml), triphenyl phosphine (18.8 g) and sodium iodide (1 g) were boiled under reflux for 100 minutes. The precipitates were collected by filtration and washed with ethyl acetate to give [4-benzhydryloxycarbonyl-7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-cephem-3-ylmethyl]triphenylphosphonium chloride (syn iosmer) (31.1 g).

Workup

  1. temperatureunder reflux for 100 minutes
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-82f037c520c3434fa9868316b230a05e
Source dataset
uspto-grants-1985_10
Patent number
US04546101

Reaction notes

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