Hydrazine hydrate (1:1) → HCID 23471413, compound

HRID 465095Notes

Reaction equation

HRID 465095 reaction equation
[IH:1].[CH3:2][CH:3]([OH:12])[CH2:4][N:5]1[CH2:9][CH2:8][N:7]=[C:6]1SC.O.[NH2:14][NH2:15]>CC(O)C>[IH:1].[NH:14]([C:6]1[N:5]([CH2:4][CH:3]([CH3:2])[OH:12])[CH2:9][CH2:8][N:7]=1)[NH2:15]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 23471442HCID 23471442, compound

Product 1

HCID 23471413HCID 23471413, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
-10 °C

Procedure

A solution of 30.2 g of α-methyl-2-(methylthio)-2-imidazoline-1-ethanol, hydroiodide, 5.2 ml of hydrazine hydrate and 200 ml of 2-propanol was refluxed for 4 hours, clarified and cooled at -10° C. The solid was collected, washed with 100 ml of cold 2-propanol, then 200 ml of ether and dried at 60° C. in vacuo, giving 26.0 g of the desired intermediate, mp 140°-142° C.

Workup

  1. customThe solid was collected
  2. washwashed with 100 ml of cold 2-propanol
  3. dry with material200 ml of ether and dried at 60° C. in vacuo

Sources & evidence

ORD record
ord-2e554dfbed0846db89c1efdd7b379b5e
Source dataset
uspto-grants-1985_10
Patent number
US04550169

Reaction notes

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