反应详情

温度

50 °C

Sodium (Aldrich, lot #9621CL, 4.1 g, 176.9 mmol) was reacted with 150 mL of isopropanol, 2-Amino-6-chloropurine (Sigma, lot #69F4064, 6.0 g, 35.4 mmol) was added and the reaction stirred at 50° C. for 24 hours. The solution was cooled and brought to pH 7 with 1N HCl. The solvents were evaporated to one-half volume. The precipitate was filtered, washed with water and dried to give 5.9 g (30.5 mmol, 87%); mp=204°-206° C.

1. additionwas added
2. temperatureThe solution was cooled
3. customThe solvents were evaporated to one-half volume
4. filtrationThe precipitate was filtered
5. washwashed with water
6. customdried
7. customto give 5.9 g (30.5 mmol, 87%)