反应详情

温度

24 °C

1,1'-Carbonyl-diimidazole (5.35 g; 0.033 mol) is added to a solution of mefanamic acid (7.2% g; 0.03 mol) in dry DMF (100 ml). The solution is stirred at 24° C. for 20 hours and then briefly warmed to 50° C. N-Methylhydroxylamine hydrochloride (2.7 g; 0.032 mo) is added to the cooled solution at 24° C. and stirred for two days. The reaction mixture is then evaporated to dryness and the residue is taken up in CH2Cl2, washed with water, and dried over sodium sulfate and evaporated. The residue is flash chromatographed through silica gel and eluted with n-hexane-CH2Cl2 -EtOAc (2:1:1) yielding a crude product which is rechromatographed through silica gel and eluted with n-hexane-CH2Cl2 -EtOAc (4:5:1). The product is recrystallized from n-pentane to give white crystals. Yield 1.5 g (18.5%); mp 70°-71° C.

1. temperaturebriefly warmed to 50° C
2. stirringstirred for two days
3. customThe reaction mixture is then evaporated to dryness
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. customevaporated
7. customchromatographed through silica gel
8. washeluted with n-hexane-CH2Cl2 -EtOAc (2:1:1)