Bis(2-chloroethyl) ether → 1,5-Bis(4-iodophenoxy)-3-oxapentane

HRID 466950Notes

Reaction equation

HRID 466950 reaction equation
[OH-:1].[Na+].[I:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.Cl[CH2:12][CH2:13][O:14][CH2:15][CH2:16]Cl>C(O)CCC>[I:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:1][C:7]2[CH:8]=[CH:9][C:4]([I:3])=[CH:5][CH:6]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 8115Bis(2-chloroethyl) etherHCID 108944-IodophenolHCID 14798Sodium Hydroxide

Product 1

HCID 190219571,5-Bis(4-iodophenoxy)-3-oxapentane

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent2×

Procedure

A mixture prepared by adding 3.08 g of sodium hydroxide and 40 ml of n-butanol to 15.4 g of 4-iodophenol was refluxed. 2 ml of n-butanol solution of 5.01 g of 1,5-dichloro-3-oxapentane was added dropwise to the above prepared mixture over a period of 5 minutes.

Workup

  1. customA mixture prepared
  2. temperaturewas refluxed

Sources & evidence

ORD record
ord-e2c411fd6c3544b8a2d1799b7d87fe83
Source dataset
uspto-grants-1992_10
Patent number
US05158850

Reaction notes

Loading…