反应详情

To 8.0 g of 4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole-2-thione in 100 ml of dimethylformamide was added 1.56 g of sodium hydride (50% in mineral oil). The mixture was stirred until the evolution of hydrogen ceased. At this point 3.9 g of isopropyl bromide was added with a syringe. After stirring for 3 hours the mixture was poured into water, filtered and air dried. Trituration with ether, filtering and drying gave 5.73 g. Recrystallizing a 3.0 g sample from ethanol gave 1.4 g of the title compound, m.p. 263°-264°.

1. filtrationfiltered
2. customair dried
3. filtrationTrituration with ether, filtering
4. customdrying
5. customgave 5.73 g
6. customRecrystallizing a 3.0 g sample from ethanol