反应详情

The title compound was prepared according to the general procedure (Method B) by coupling Intermediate 7 (80 mg, 0.318 mmol) with 4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine (84 mg, 0.318 mmol) in the presence of EDCI hydrochloride (74 mg, 0.381 mmol), HOBt (13 mg, 0.096 mmol) and DMAP (4 mg, 0.032 mmol) in 1,2-dichloroethane (4 mL) to give 52 mg of the product as an off white solid; 1H-NMR (δ ppm, DMSO-d6, 300 MHz) 3.21 (s, 3H), 3.73 (s, 3H), 3.80 (s, 3H), 3.95 (s, 2H), 6.35 (s, 1H), 7.82-8.02 (m, 4H), 12.62 (br s, 1H, exchangeable with D2O); APCI-MS (m/z) 496.26 (M+H)+.