Hydrochloric Acid → HCID 28750082, compound

Sodium hydride 55% in oil (1.4 g; 29.8 mmol) was added portionwise over 10 minutes to a stirred solution of 2,4,6-trichlorophenol (5.89 g; 29.8 mmol) in dry dimethylformamide (90 ml) at a temperature of 10° C. under nitrogen. The reaction mixture was stirred for 20 minutes at ambient temperature followed by the addition of (S)-tetrahydro-pyrrolo[1,2-c][1,2,3]oxathiazole 1,1-dioxide (5.0 g; 30.6 mmol), which was prepared as described in example P14, in dimethylformamide (25 ml). The reaction mixture was stirred for 4 hours at ambient temperature then poured onto 1M HCl (400 ml) and extracted with ethyl acetate (2×200 ml). The combined ethyl acetate layers are washed with water (2×100 ml), saturated NaCl (100 ml) and then dried over Na2SO4. After removal of the solvent the residue (11.1 g oil) was dissolved in dioxane (150 ml) and treated with sulphuric acid (2.9 ml) and water (2.9 ml). The reaction mixture was stirred at ambient temperature for 15 hours. The reaction mixture was poured on sat. NaHCO3 (300 ml) and extracted with dichloromethane (3×200 ml). The organic layers are washed with saturated NaCl (100 ml) and then dried over Na2SO4. After evaporation of the solvent, the crude product (7.16 g in the form of a orange oil) was purified by flash chromatography over silica gel (eluent:dichloromethane/methanol 9:1) to afford 3.53 g (42.0% of theory) of (S)-2-(2,4,6-trichloro-phenoxymethyl)-pyrrolidine as a oil.

1. customwas prepared
2. stirringThe reaction mixture was stirred for 4 hours at ambient temperature
3. extractionextracted with ethyl acetate (2×200 ml)
4. washThe combined ethyl acetate layers are washed with water (2×100 ml), saturated NaCl (100 ml)
5. dry with materialdried over Na2SO4
6. customAfter removal of the solvent the residue (11.1 g oil)
7. dissolutionwas dissolved in dioxane (150 ml)
8. additiontreated with sulphuric acid (2.9 ml) and water (2.9 ml)
9. stirringThe reaction mixture was stirred at ambient temperature for 15 hours
10. additionThe reaction mixture was poured on sat. NaHCO3 (300 ml)
11. extractionextracted with dichloromethane (3×200 ml)
12. washThe organic layers are washed with saturated NaCl (100 ml)
13. dry with materialdried over Na2SO4
14. customAfter evaporation of the solvent
15. customthe crude product (7.16 g in the form of a orange oil) was purified by flash chromatography over silica gel (eluent:dichloromethane/methanol 9:1)

ORD record

ord-af5d69016b1a4c2abc1e6054b4ac18cd

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08623902B2