反应详情

A mixture of 1-methylpiperazine (600 mg, 1.5 mmol), ethyl 4-(bromomethyl)-3-(trifluoromethyl)benzoate (310 mg, 1.0 mmol), and potassium carbonate (276 mg, 2.0 mmol) in N,N-dimethylformamide (8 mL) were stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue was diluted with ethyl acetate and water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried and concentrated to give the product without further purification (600 mg, 72%).

1. customThe solvent was removed under reduced pressure
2. additionthe residue was diluted with ethyl acetate and water
3. extractionThe aqueous layer was extracted with ethyl acetate
4. customThe combined organic layers were dried
5. concentrationconcentrated
6. customto give the product
7. customwithout further purification (600 mg, 72%)