1,1'-Carbonyldiimidazole → HCID 67329876, compound

HRID 468991Notes

Reaction equation

HRID 468991 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([OH:23])=O)[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.CCN(C(C)C)C(C)C.Cl.[I-:47].[NH2:48][CH2:49][CH2:50][C:51]1[CH:56]=[CH:55][C:54]([NH:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][N+:59]=2[CH3:64])=[CH:53][CH:52]=1>ClCCCl>[I-:47].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([NH:48][CH2:49][CH2:50][C:51]3[CH:52]=[CH:53][C:54]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[CH:60][N+:59]=4[CH3:64])=[CH:55][CH:56]=3)=[O:23])[CH:17]=2)[CH3:14])(=[O:11])=[O:12])=[C:7]([CH3:9])[CH:8]=1

Participants

6

Reactant 4

HCID 682631,1'-CarbonyldiimidazoleHCID 81531DiisopropylethylamineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acidHCID 67216866HCID 67216866, compound

Product 1

HCID 67329876HCID 67329876, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to general procedure AD using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (50 mg, 0.13 mmol), CDI (33 mg, 0.2 mmol), DIPEA (0.14 mL, 0.81 mmol) and 2-{[4-(2-aminoethyl)phenyl]amino}-1-methylpyridinium iodide hydrochloride (55 mg, 0.14 mmol) in DCE (1.0 mL).

Sources & evidence

ORD record
ord-ecefe07fc6b74c349f4f86efdd802122
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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