1,1'-Carbonyldiimidazole → HCID 46175544, compound

HRID 468992Notes

Reaction equation

HRID 468992 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([OH:23])=O)[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.Cl.Cl.[NH2:39][CH2:40][C:41]1[CH:46]=[CH:45][C:44]([NH:47][C:48]2[N:53]=[C:52]([NH2:54])[CH:51]=[CH:50][N:49]=2)=[CH:43][CH:42]=1.CCN(C(C)C)C(C)C>ClCCCl>[NH2:54][C:52]1[CH:51]=[CH:50][N:49]=[C:48]([NH:47][C:44]2[CH:45]=[CH:46][C:41]([CH2:40][NH:39][C:21]([C:18]3[CH:17]=[C:16]([CH2:15][N:13]([S:10]([C:6]4[C:5]([CH3:24])=[CH:4][C:3]([O:2][CH3:1])=[CH:8][C:7]=4[CH3:9])(=[O:12])=[O:11])[CH3:14])[O:20][CH:19]=3)=[O:23])=[CH:42][CH:43]=2)[N:53]=1

Participants

6

Reactant 4

HCID 682631,1'-CarbonyldiimidazoleHCID 81531DiisopropylethylamineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acidHCID 86712427HCID 86712427, compound

Product 1

HCID 46175544HCID 46175544, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to general procedure AE using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (60 mg, 0.16 mmol), CDI (48 mg, 0.29 mmol), N2-[4-(aminomethyl)phenyl]pyrimidine-2,4-diamine dihydrochloride (46 mg, 0.15 mmol) and DIPEA (0.17 mL, 0.97 mmol) in DCE (2 mL).

Sources & evidence

ORD record
ord-5dcf0777329d414e9d30d36ad75f764c
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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