1,1'-Carbonyldiimidazole → HCID 46175543, compound

HRID 468993Notes

Reaction equation

HRID 468993 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:13][C:14]2[O:18][CH:17]=[C:16]([C:19]([OH:21])=O)[CH:15]=2)[CH3:12])(=[O:10])=[O:9])=[C:4]([CH2:22][CH3:23])[CH:3]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[N:36]1([CH2:41][CH2:42][CH2:43][N:44]2[CH2:50][CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH2:40][CH2:39][CH2:38][CH2:37]1>ClCCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH3:12])[CH2:13][C:14]2[O:18][CH:17]=[C:16]([C:19]([N:47]3[CH2:48][CH2:49][CH2:50][N:44]([CH2:43][CH2:42][CH2:41][N:36]4[CH2:37][CH2:38][CH2:39][CH2:40]4)[CH2:45][CH2:46]3)=[O:21])[CH:15]=2)(=[O:9])=[O:10])=[C:4]([CH2:22][CH3:23])[CH:3]=1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 27372511-[3-(pyrrolidin-1-yl)propyl]-1,4-diazepaneHCID 58393320HCID 58393320, compound

Product 1

HCID 46175543HCID 46175543, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to general procedure AA using 5-({[(4-bromo-2-ethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (50 mg, 0.12 mmol), CDI (41 mg, 0.25 mmol) and 1-[3-(pyrrolidin-1-yl)propyl]-1,4-diazepane (53 mg, 0.25 mmol) in DCE (2 mL). The crude product was purified using prep method A.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-d5f66385393c45dc923593333fbfa5ec
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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