1,1'-Carbonyldiimidazole → HCID 46175542, compound

HRID 468994Notes

Reaction equation

HRID 468994 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:13][C:14]2[O:18][CH:17]=[C:16]([C:19](O)=[O:20])[CH:15]=2)[CH3:12])(=[O:10])=[O:9])=[C:4]([CH2:22][CH3:23])[CH:3]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[N:36]1([CH2:41][C:42]2[CH:43]=[C:44]([CH2:48][NH2:49])[CH:45]=[CH:46][CH:47]=2)[CH2:40][CH2:39][CH2:38][CH2:37]1>ClCCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:13][C:14]2[O:18][CH:17]=[C:16]([C:19]([NH:49][CH2:48][C:44]3[CH:45]=[CH:46][CH:47]=[C:42]([CH2:41][N:36]4[CH2:40][CH2:39][CH2:38][CH2:37]4)[CH:43]=3)=[O:20])[CH:15]=2)[CH3:12])(=[O:9])=[O:10])=[C:4]([CH2:22][CH3:23])[CH:3]=1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 47124781-{3-[(Pyrrolidin-1-yl)methyl]phenyl}methanamineHCID 58393320HCID 58393320, compound

Product 1

HCID 46175542HCID 46175542, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to general procedure AA using 5-({[(4-bromo-2-ethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (40 mg, 0.10 mmol), CDI (32 mg, 0.2 mmol) and 1-[3-(pyrrolidin-1-ylmethyl)phenyl]methanamine (57 mg, 0.3 mmol) in DCE (2 mL). The crude product was purified using prep method A.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-e11fe79c16e94755835cdab50ff90f6d
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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