1,1'-Carbonyldiimidazole → HCID 58393196, compound

HRID 469008Notes

Reaction equation

HRID 469008 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([OH:23])=O)[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH:37]1[CH2:41][CH2:40][N:39]=[C:38]1[C:42]1[CH:47]=[CH:46][C:45]([CH:48]2[CH2:53][CH2:52][CH2:51][NH:50][CH2:49]2)=[CH:44][CH:43]=1.CCN(C(C)C)C(C)C>ClCCCl>[NH:39]1[CH2:40][CH2:41][N:37]=[C:38]1[C:42]1[CH:43]=[CH:44][C:45]([CH:48]2[CH2:53][CH2:52][CH2:51][N:50]([C:21]([C:18]3[CH:17]=[C:16]([CH2:15][N:13]([CH3:14])[S:10]([C:6]4[C:5]([CH3:24])=[CH:4][C:3]([O:2][CH3:1])=[CH:8][C:7]=4[CH3:9])(=[O:11])=[O:12])[O:20][CH:19]=3)=[O:23])[CH2:49]2)=[CH:46][CH:47]=1

Participants

6

Reactant 4

HCID 682631,1'-CarbonyldiimidazoleHCID 81531DiisopropylethylamineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acidHCID 58393398HCID 58393398, compound

Product 1

HCID 58393196HCID 58393196, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to general procedure AA using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (60 mg, 0.15 mmol), CDI (51 mg, 0.31 mmol), 3-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]piperidine (49 mg, 0.15 mmol) and DIPEA (0.134 mL, 0.76 mmol) in DCE (1.2 mL).

Sources & evidence

ORD record
ord-5ead15b6e2004fe8b06bc32953f70d9c
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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