1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-(4-{[{[5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)furan-3-yl]carbonyl}(methyl)amino]methyl}benzyl)-N,N-dimethylpyrrolidine-3-carboxamide
Reaction equation
[CH:1]1([N:4]([CH2:18][C:19]2[O:23][CH:22]=[C:21]([C:24]([OH:26])=O)[CH:20]=2)[S:5]([C:8]2[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=2[CH3:17])(=[O:7])=[O:6])[CH2:3][CH2:2]1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C.Cl.Cl.[CH3:59][N:60]([CH3:78])[C:61]([CH:63]1[CH2:67][CH2:66][N:65]([CH2:68][C:69]2[CH:74]=[CH:73][C:72]([CH2:75][NH:76][CH3:77])=[CH:71][CH:70]=2)[CH2:64]1)=[O:62]>C(Cl)Cl>[CH:1]1([N:4]([CH2:18][C:19]2[O:23][CH:22]=[C:21]([C:24]([N:76]([CH2:75][C:72]3[CH:71]=[CH:70][C:69]([CH2:68][N:65]4[CH2:66][CH2:67][CH:63]([C:61]([N:60]([CH3:59])[CH3:78])=[O:62])[CH2:64]4)=[CH:74][CH:73]=3)[CH3:77])=[O:26])[CH:20]=2)[S:5]([C:8]2[C:9]([CH3:17])=[CH:10][C:11]([O:15][CH3:16])=[CH:12][C:13]=2[CH3:14])(=[O:7])=[O:6])[CH2:2][CH2:3]1Participants
7
Reactant 5
HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide
HCID 757711-Hydroxybenzotriazole
HCID 81531Diisopropylethylamine
HCID 583933505-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)furan-3-carboxylic acid
HCID 67217657N,N-dimethyl-1-{4-[(methylamino)methyl]benzyl}pyrrolidine-3-carboxamide dihydrochlorideProduct 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared according to general procedure BH using 5-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)furan-3-carboxylic acid (40 mg, 0.105 mmol), EDCI (28 mg, 0.158 mmol), HOBt (21 mg, 0.16 mmol), DIPEA (0.04 mL, 0.21 mmol), N,N-dimethyl-1-{4-[(methylamino)methyl]benzyl}pyrrolidine-3-carboxamide dihydrochloride (40 mg, 0.12 mmol) and DCM (5 mL).
Sources & evidence
- ORD record
- ord-31ce596be3ef48b19a96ccb1d0d7bd3e
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08623859B2
Reaction notes
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