Diisopropylethylamine → HCID 86630130, compound

HRID 469138Notes

Reaction equation

HRID 469138 reaction equation
[CH3:1][N:2]([C:4]([O:8][N:9]1[N:17]=[N:16][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]1=2)=[N+:5]([CH3:7])[CH3:6])[CH3:3].[B-:18]([F:22])([F:21])([F:20])[F:19].OC1C2N=NNC=2C=CC=1.CCN(C(C)C)C(C)C>CN1C(=O)CCC1>[CH3:7][N:5]([C:4]([O:8][N:9]1[N:17]=[N:16][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]1=2)=[N+:2]([CH3:1])[CH3:3])[CH3:6].[B-:18]([F:22])([F:21])([F:20])[F:19].[CH:13]1[CH:14]=[CH:15][C:10]2[N:9]([OH:8])[N:17]=[N:16][C:11]=2[CH:12]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 178418300HCID 178418300, compound

Product 1

HCID 86630130HCID 86630130, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of Fmoc-Xaa-OH (2 eq.), TBTU (2 eq.), HOBt (hydroxybenzotriazole) (2 eq.), DIEA (5.2 eq.) in NMP was added to the resin-bound free amine peptide and shaken for 60 min at room temperature and washed with NMP (5×).

Workup

  1. washwashed with NMP (5×)

Sources & evidence

ORD record
ord-5993e88ac0f047dfbfd4897d9fdb9bad
Source dataset
uspto-grants-2014_01
Patent number
US08628750B2

Reaction notes

Loading…