Water → HCID 25271153, compound

HRID 469412Notes

Reaction equation

HRID 469412 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:8](=[O:17])[NH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:3][CH2:2]1.Cl[C:19]1[N:24]=[CH:23][N:22]=[C:21]([C:25]([C:27]2[CH:37]=[C:36]([CH3:38])[C:30]3[N:31]([CH3:35])[C:32](=[O:34])[O:33][C:29]=3[CH:28]=2)=[O:26])[CH:20]=1.CCN(C(C)C)C(C)C.O>CN(C=O)C>[CH3:35][N:31]1[C:30]2[C:36]([CH3:38])=[CH:37][C:27]([C:25]([C:21]3[N:22]=[CH:23][N:24]=[C:19]([N:1]4[CH2:2][CH2:3][CH:4]([C:7]5[C:8](=[O:17])[NH:9][C:10]6[C:15]([CH:16]=5)=[CH:14][CH:13]=[CH:12][CH:11]=6)[CH2:5][CH2:6]4)[CH:20]=3)=[O:26])=[CH:28][C:29]=2[O:33][C:32]1=[O:34]

Participants

6

Reactant 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 183210463-(Piperidin-4-yl)quinolin-2(1H)-oneHCID 581811626-(6-chloropyrimidine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one

Product 1

HCID 25271153HCID 25271153, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

60 mg (0.26 mmol) 3-piperidin-4-yl-1H-quinolin-2-one, 80 mg (0.26 mmol) 6-(6-chloropyrimidine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one and 0.15 mL (0.86 mmol) DIPEA were combined in 3 mL DMF and stirred overnight at RT. The reaction mixture was added to water and the precipitate formed was suction filtered, washed with MeOH and dried.

Workup

  1. customthe precipitate formed
  2. filtrationfiltered
  3. washwashed with MeOH
  4. customdried

Sources & evidence

ORD record
ord-e157e1b00ffd4cc588b23595d5890327
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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