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HRID469433

反应详情

EQUATION

反应方程式

HRID 469433 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：Cl.Cl.O=c1[nH]c2ncccc2n1C1CCNCC1
HCID22293181

1-(Piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one--hydrogen chloride (1/2)

C11H16Cl2N4O

结构：Cc1cc(C(=O)c2cc(Cl)ncn2)cc2c1OCC2
HCID58181093

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)cc2c1OCC2.O=C[O-]
HCID131731130

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl
催化剂HCID313

Hydrochloric Acid

ClH

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

0.11 g (0.36 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one-dihydrochloride, 90 mg (0.23 mmol) (6-chloro-pyrimidin-4-yl)-(7-methyl-2,3-dihydro-benzofuran-5-yl)-methanone and 0.20 mL (1.16 mmol) DIPEA were combined in 1.5 mL DMF and stirred for 48 h at RT. Then the reaction mixture was mixed with a few drops of hydrochloric acid and purified by preparative HPLC-MS. The fractions containing the product were combined and freeze-dried.

WORKUP

后处理

  1. custompurified by preparative HPLC-MS
  2. additionThe fractions containing the product
  3. customfreeze-dried