Tetrahydrofuran → 1013643-07-6

HRID 469818Notes

Reaction equation

HRID 469818 reaction equation
[Br:1][C:2]1[C:7]([OH:8])=[C:6]([N+:9]([O-])=O)[CH:5]=[CH:4][N:3]=1.C1COCC1>CO.[Pt]>[NH2:9][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([Br:1])[C:7]=1[OH:8]

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 53416660HCID 53416660, compound

Product 1

HCID 867622171013643-07-6

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A solution of 5.3 g (22.7 mmol) 2-bromo-4-nitro-pyridin-3-ol in 100 ml MeOH:THF=1:2 is hydrogenated in the presence of 0.5 g Pt/C (5%, Engelhard 4709). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound as a brown solid.

Workup

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-39337ffe6abd4520b32a4ed1f6a102d3
Source dataset
uspto-grants-2014_01
Patent number
US08629168B2

Reaction notes

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