反应详情

温度

80 °C

In n-propanol (42 ml) was dissolved 2,3-dimethyl-4-nitropyridine-1-oxide (841 mg). To the solution was added anhydrous potassium carbonate (2.1 g), and the mixture was stirred at 80° C. for 22 hours, followed by filtration with celite. The filtrate was concentrated, and the residue was chromatographed on a column of silica-gel (50 g), which was eluted with 5% methanol.chloroform to yield 2,3-dimethyl-4-propoxypyridine-1-oxide (360 mg) as an oily substance.

1. filtrationfollowed by filtration with celite
2. concentrationThe filtrate was concentrated
3. customthe residue was chromatographed on a column of silica-gel (50 g), which
4. washwas eluted with 5% methanol