反应详情

To a solution of 0.93 g (13.4 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 1.66 g (19.78 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 1.0 g (8.9 mmol) of hexanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After completion of the reaction, the reaction mixture was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue, which was chased with 5 mL of toluene, to yield the title compound.

1. stirringstirred at 80° C. to 85° C. for 3-4 h
2. customAfter completion of the reaction
3. temperaturethe reaction mixture was cooled to 25° C. to 30° C.
4. filtrationfiltered
5. washwashed with 2 mL of isopropyl alcohol
6. customThe filtrate was collected
7. distillationdistilled out completely
8. customto obtain a crude residue, which