反应详情

1,3-dibromopropane (20.0 g) was added to a stirred suspension of 4-hydroxybenzaldehyde (4.0 g) and potassium carbonate (7.0 g) in acetone (80 mL). After 16 h, the mixture was heated under reflux for a further 2 h, cooled, filtered to remove the inorganics, and the solution was evaporated in vacuo. Purification was by silica gel chromatography eluting with isohexane to remove the 1,3-dibromopropane and then dichloromethane:isohexane, 2:1 to collect the subtitled compound. Yield 3.45 g.

1. temperaturethe mixture was heated
2. temperatureunder reflux for a further 2 h
3. temperaturecooled
4. filtrationfiltered
5. customto remove the inorganics
6. customthe solution was evaporated in vacuo
7. customPurification
8. washeluting with isohexane
9. customto remove the 1,3-dibromopropane
10. customdichloromethane:isohexane, 2:1 to collect the subtitled compound