反应详情

Lithium hydroxide monohydrate (4.4 g) was added to a solution of ethyl 2-propylthiazole-4-carboxylate (example 87, step b) (5.24 g) in a mixture of THF (80 mL) and water (20 mL). The resulting mixture was stirred overnight. The reaction was acidified with concentrated hydrochloric acid and the volatiles evaporated. The resulting aqueous mixture was saturated with sodium chloride and extracted with ethyl acetate (3×100 mL). The combined organic solutions were dried over sodium sulphate, filtered and evaporated to give the subtitled compound as a white solid. Yield 2.5 g.

1. customthe volatiles evaporated
2. extractionextracted with ethyl acetate (3×100 mL)
3. dry with materialThe combined organic solutions were dried over sodium sulphate
4. filtrationfiltered
5. customevaporated