huagongshe.com
HRID473546

反应详情

EQUATION

反应方程式

HRID 473546 的结构方程式

REACTANTS

反应物

4
结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：CC(C)COC(=O)Cl
HCID62365

Isobutyl chloroformate

C5H9ClO2

结构：CN1CCC(C(=O)O)CC1
HCID2736939

1-methylpiperidine-4-carboxylic acid

C7H13NO2

结构：CCOC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)(C)C
HCID86674878

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C1CCN(C)CC1)C(C)(C)C
HCID67325020

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

For compound (A48) (S)-2-((S)-2-Amino-3,3-dimethyl-butyrylamino)-propionic acid ethyl ester was coupled with 1-Methyl-piperidine-4-carboxylic acid using isobutylchloroformate and N-methylmorpholine in DMF to give (S)-2-{(S)-3,3-Dimethyl-2-[(1-methyl-piperidine-4-carbonyl)-amino]-butyrylamino}-propionic acid ethyl ester. This was then quaternised with Mel in DCM-acetone and subsequently hydrolysed using an hydroxide resin such as Ambersep 900-OH resin.