Diisopropylethylamine → HCID 71529533, compound

HRID 475217Notes

Reaction equation

HRID 475217 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[NH:13][N:12]=[C:11]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=2)[CH:5]=[CH:4][N:3]=1.[F:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:27][NH2:28])=[C:22]2[C:26]=1[NH:25][CH:24]=[CH:23]2.CCN(C(C)C)C(C)C>CC(O)C>[CH:14]1([C:11]2[NH:12][N:13]=[C:9]([NH:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:28][CH2:27][C:21]4[CH:20]=[CH:19][C:18]([F:17])=[C:26]5[C:22]=4[CH:23]=[CH:24][NH:25]5)[N:7]=3)[CH:10]=2)[CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 76846761HCID 76846761, compoundHCID 178478345HCID 178478345, compound

Product 1

HCID 71529533HCID 71529533, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
120 °C

Procedure

A tube was charged with 53 (63 mg, 0.27 mmol), 114 (44 mg, 0.27 mmol), DIPEA (2 mL) in IPA (5 mL), degassed, sealed and heated at 120° C. overnight. The solvent was evaporated in vacuo and the residue was purified by preparative HPLC to afford 56 mg (57%) of I-47 as white solid.

Workup

  1. customdegassed
  2. customsealed
  3. customThe solvent was evaporated in vacuo
  4. customthe residue was purified by preparative HPLC
  5. customto afford 56 mg (57%) of I-47 as white solid

Sources & evidence

ORD record
ord-0ab753f48c8f4a90ac7596c51350197d
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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