Diisopropylethylamine → HCID 86694752, compound

HRID 475281Notes

Reaction equation

HRID 475281 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]2[NH:8][CH:9]=[N:10][C:6]=2[C:5]=1[CH3:13].Cl[C:15]1[N:20]=[C:19]([NH:21][C:22]2[NH:26][N:25]=[C:24]([CH:27]3[CH2:29][CH2:28]3)[CH:23]=2)[CH:18]=[CH:17][N:16]=1.CCN(C(C)C)C(C)C>CC(O)C>[CH:27]1([C:24]2[NH:25][N:26]=[C:22]([NH:21][C:19]3[CH:18]=[CH:17][N:16]=[C:15]([N:2]([CH3:1])[CH2:3][C:4]4[CH:12]=[CH:11][C:7]5[NH:8][CH:9]=[N:10][C:6]=5[C:5]=4[CH3:13])[N:20]=3)[CH:23]=2)[CH2:29][CH2:28]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 86694750HCID 86694750, compoundHCID 178478345HCID 178478345, compound

Product 1

HCID 86694752HCID 86694752, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
120 °C

Procedure

A tube was charged with 264 (40 mg, 0.23 mmol), 53 (100 mg, 0.57 mmol), and DIPEA (0.3 ml) in IPA (3 mL), degassed, sealed and heated at 120° C. overnight. After removal of the solvent in vacuo, the crude was purified by preparative HPLC to afford 25 mg (29%) of I-95 as white solid.

Workup

  1. customdegassed
  2. customsealed
  3. customAfter removal of the solvent in vacuo
  4. customthe crude was purified by preparative HPLC
  5. customto afford 25 mg (29%) of I-95 as white solid

Sources & evidence

ORD record
ord-746dd404613146aa9787b49b14918dde
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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