4-Methoxybenzylamine → 2-Chloro-9-isopropyl-N-(4-methoxybenzyl)-9H-purin-6-amine

HRID 478482Notes

Reaction equation

HRID 478482 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4](Cl)[N:3]=1.[CH3:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19][CH:18]=1>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4]([NH:22][CH2:21][C:20]2[CH:23]=[CH:24][C:17]([O:16][CH3:15])=[CH:18][CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 754524-MethoxybenzylamineHCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

Product 1

HCID 98587852-Chloro-9-isopropyl-N-(4-methoxybenzyl)-9H-purin-6-amine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-[(4-methoxybenzyl)amino]-9-(2-propyl)purine is prepared from 2,6-dichloro-9-(2-propyl)purine (see Example 19 for preparation), 4-methoxybenzylamine, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-65746d6c97264ccaa71270c983479adc
Source dataset
uspto-grants-2003_11
Patent number
US06642231B2

Reaction notes

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