反应详情

温度

130 °C

A mixture of 0.5 g of 3-methyl-1-indanone, 1.37 g oxindole and 5 ml piperidine in 3 ml of dimethylforamide was heated in a sealed tube at 130° C. overnight to yield a reddish-brown suspension. The mixture was added to 1N hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried with magnesium sulfate and concentrated. Chromatography afforded 120 mg of 3-(3-methylindan-1-ylidene)-1,3-dihydroindol-2-one as an orange solid.

1. customto yield a reddish-brown suspension
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with brine
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated