Imidazole → HCID 11829501, compound

HRID 479085Notes

Reaction equation

HRID 479085 reaction equation
[CH:1]1([C:4](Cl)=[O:5])[CH2:3][CH2:2]1.[NH:7]1[CH:11]=[CH:10][N:9]=[CH:8]1>O1CCCC1>[CH:1]1([C:4]([N:7]2[CH:11]=[CH:10][N:9]=[CH:8]2)=[O:5])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 77637Cyclopropanecarbonyl chloride

Product 1

HCID 11829501HCID 11829501, compoundYield 102.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of cyclopropanecarbonyl chloride (10.0 g) in dry tetrahydrofuran was added dropwise to a solution of imidazole (13.0 g, 2 equivalents) stirred at 0° C. After 1 hour the solid was filtered and the filtrate evaporated to give the title compound (13.3 g), NMR 1.2 (m, 2H), 1.38 (m, 2H), 2.21 (m, 1H), 7.12 (d, 1H), 7.55 (d, 1H), 8.34 (s, 1H).

Workup

  1. filtrationAfter 1 hour the solid was filtered
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-aeb4debf6a98429a89e093bb05b5679d
Source dataset
uspto-grants-2003_11
Patent number
US06642418B1

Reaction notes

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