Dimethylformamide → HCID 178520390, compound

HRID 479931Notes

Reaction equation

HRID 479931 reaction equation
[CH3:1][N:2]([CH3:5])C=O.Br[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:9].[NH:16]1C=CN=[N:17]1.C(=O)([O-])[O-].[K+].[K+]>O>[NH:16]1[CH:1]=[N:2][C:5]([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[N:17]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6259Phenacyl bromideHCID 11430Potassium CarbonateHCID 178418936HCID 178418936, compound

Product 1

HCID 178520390HCID 178520390, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 20 ml of dimethylformamide, 1.99 g of bromoacetophenone, 0.69 g of triazole, and 2 g of potassium carbonate were added, and the mixture was allowed to react at room temperature for 16 hours. The reaction mixture was poured into 100 ml of water, and the deposited crystals were collected by filtration, which were recrystallized from ethyl acetate/hexane to obtain the desired compound (yield: 85%).

Workup

  1. customto react at room temperature for 16 hours
  2. filtrationthe deposited crystals were collected by filtration, which
  3. customwere recrystallized from ethyl acetate/hexane

Sources & evidence

ORD record
ord-40740d4b3ea24558aaea26edaa387acc
Source dataset
uspto-grants-2003_11
Patent number
US06649568B2

Reaction notes

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