反应详情

温度

0 °C

Methyl bromoacetate (10 g, 65.4 mmol, 1.0 equiv) was dissolved in 100 mL of CH2Cl2 which was then cooled to 0° C. N-Methylbenzylamine (7.92 g, 65.4 mmol, 1.0 equiv) was added dropwise over a 10 min period at which time Hunig's base (21 g, 163 mmol, 2.49 equiv) was added and the reaction was allowed to warm to room temperature and was stirred for 16 h. The reaction was diluted with 50 mL of saturated bicarbarbonate and the layers were separated. The organic layer was washed once more with 50 mL of sodium bicarbonate, dried over Na2SO4, decanted and concentrated to a yellow oil which was used in the next step without further purification.

1. additionwas added
2. temperatureto warm to room temperature
3. additionThe reaction was diluted with 50 mL of saturated bicarbarbonate
4. customthe layers were separated
5. washThe organic layer was washed once more with 50 mL of sodium bicarbonate
6. dry with materialdried over Na2SO4
7. customdecanted
8. concentrationconcentrated to a yellow oil which
9. customwas used in the next step without further purification