HRID48102

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID21976917

未命名化合物

PRODUCTS

生成物

结构：[Br-].c1ccc(COc2ccc3cc(C[P+](c4ccccc4)(c4ccccc4)c4ccccc4)ccc3c2)cc1

HCID20632177

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The solution of 2-benzyloxy-6-bromomethyl-naphthalen (18) (1 equi.), and triphenylphosphine (1.1 equi.) in DMF (0.6 mL/mmole was stirred at 95 C for 15 h, cooled to room temperature, and quenched with ethyl acetate. The resulting white solid of (6-benzyloxynaphthalen-2-ylmethyl)-triphenylphosphonium bromide (19) was filtered and washed with ethyl acetate. Yield 98%.

WORKUP

后处理

customquenched with ethyl acetate
filtrationThe resulting white solid of (6-benzyloxynaphthalen-2-ylmethyl)-triphenylphosphonium bromide (19) was filtered
washwashed with ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-20e0aff8f86642d8a7a609f7ea37c173
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06703082B1
来源说明: uspto-grants-2004_03

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:19][Br:20])[CH:15]=2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]1([P:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CN(C=O)C>[Br-:20].[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([CH2:19][P+:27]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1