Hydrochloric Acid → HCID 67662847, compound

HRID 481302Notes

Reaction equation

HRID 481302 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12]C)=[O:11])=[CH:5][CH:4]=1.[C:14]1([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(N(CC)CC)C.[ClH:33]>O1CCOCC1>[ClH:33].[C:14]1([N:20]2[CH2:25][CH2:24][N:23]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=3)[CH2:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 70961-PhenylpiperazineHCID 8471TriethylamineHCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetate

Product 1

HCID 67662847HCID 67662847, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using 2.3 g of methyl 4-bromomethylphenylacetate, 2.0 g of 1-phenylpiperazine, 2 ml of triethylamine, and 80 ml of dioxane, the reaction procedure of Example 2 was otherwise repeated and the reaction product was converted to the hydrochloride using 2N-hydrochloric acid and recrystallized from methanol-ether to provide 2.0 g of the title compound melting at 231° C.-234° C.

Workup

  1. customthe reaction procedure of Example 2
  2. customrecrystallized from methanol-ether

Sources & evidence

ORD record
ord-b25f9fb4141c49d2b2ce85e0ee3dc682
Source dataset
uspto-grants-1998_08
Patent number
US05789409

Reaction notes

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