1-(2-Methoxyphenyl)piperazine → HCID 19066227, compound

HRID 481360Notes

Reaction equation

HRID 481360 reaction equation
[Cl:1][C:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2C)[CH2:6][CH2:5]1)=[O:3].[CH3:17][O:18]C1C=CC=CC=1N1CCNCC1.ClC(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl.C(N(CC)CC)C>O1CCCC1>[Cl:1][C:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:18][CH3:17])[CH2:6][CH2:5]1)=[O:3]

Participants

6

Reactant 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 8471TriethylamineHCID 94429TriphosgeneHCID 19066233HCID 19066233, compound

Product 1

HCID 19066227HCID 19066227, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 39A is prepared according to the procedure described for compound 15A, using the following reactants: 1-(o-methoxyphenyl)piperazine (441 mg, 2.3 mmol); triphosgene (210 mg, 0.7 mmol); triethylamine (315 ml, 2.3 mmol); tetrahydrofuran (30 ml).

Sources & evidence

ORD record
ord-0473b8da6b844030a892346cd1b5d465
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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