反应详情

A mixture of 56 g of 4-nitrophenol, 90 g of methyl bromoacetate, 100 g of potassium carbonate and 500 ml of dimethylformamide was stirred at room temperature for 2 days. At the end of this time, the solvent was removed by distillation under reduced pressure. The resulting residue was mixed with water and the aqueous mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, after which the solvent was removed by distillation under reduced pressure. The resulting residue was triturated with hexane to give 63.3 g of the title compound, melting at 98-99° C.

1. customAt the end of this time, the solvent was removed by distillation under reduced pressure
2. additionThe resulting residue was mixed with water
3. extractionthe aqueous mixture was extracted with ethyl acetate
4. washThe extract was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customafter which the solvent was removed by distillation under reduced pressure
7. customThe resulting residue was triturated with hexane