反应详情

温度

10 °C

Dissolved in 100 ml of dimethylformamide was 10.4 g (0.04 mole) of 1-methyl-3-(3,4-dichlorophenyl)-4-hydroxyimidazolidine-2-one. The solution was cooled to 10° C. and 2 g (0.04 mole) of sodium hydride was added to the solution with stirring. After the addition, the mixture was stirred for 30 minutes and 4.4 g of ethyl bromide was added dropwise. The mixture was stirred at room temperature for 2 hours and water was added to the reaction mixture. The mixture was extracted with chloroform and the chloroform extract was concentrated, giving 9.5 g of an oil in 82.1% yield.

1. additionAfter the addition
2. stirringthe mixture was stirred for 30 minutes
3. stirringThe mixture was stirred at room temperature for 2 hours
4. extractionThe mixture was extracted with chloroform
5. extractionthe chloroform extract
6. concentrationwas concentrated