Phosphoric Acid → HCID 70453490, compound

HRID 483103Notes

Reaction equation

HRID 483103 reaction equation
C(O[C:4](=[O:12])[CH:5]([Na])[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[H-].[Na+].C(OCC)(=O)CC(OCC)=O.[CH2:26]([O:33][C:34]([N:36]1[CH2:38][CH2:37]1)=[O:35])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.P(=O)(O)(O)O>O1CCCC1>[CH2:9]([O:8][C:6]([CH:5]1[CH2:38][CH2:37][N:36]([C:34]([O:33][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:35])[C:4]1=[O:12])=[O:7])[CH3:10]

Participants

7

Reactant 5

HCID 1004Phosphoric AcidHCID 7761Diethyl MalonateHCID 24758Sodium hydrideHCID 9855625HCID 9855625, compoundHCID 178472565HCID 178472565, compound

Product 1

HCID 70453490HCID 70453490, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of sodiomalonic acid diethyl ester prepared from sodium hydride (704 mg), diethyl malonate (3 ml), and tetrahydrofuran (10 ml) is added aziridine-1-carboxylic acid benzyl ester (1.8 g). After 22 hours at room temperature, the mixture is neutralized with 10% phosphoric acid, washed with water, dried and concentrated to give 1-carbobenzoxy-2-oxopyrroidine-3-carboxylic acid ethyl ester (1.85 g). Oil. IR (CHCl3) ν: 1785, 1730 cm-1.

Workup

  1. washwashed with water
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-db80bc780004408bb55676458d6033d0
Source dataset
uspto-grants-1986_03
Patent number
US04578378

Reaction notes

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