反应详情

温度

80 °C

A mixture of 300 mg (1.62 mmol) of 2-chloro-5-nitrobenzaldehyde, 196 mg (1.62 mmol) of N-benzylmethylamine and 268 mg (1.94 mmol) of potassium carbonate in dimethylformamide was heated at 80° C. for 5 hour. The solvent was removed and the residue was partitioned between water and ethyl acetate (×2). The combined organic phases were evaporated and the residue was purified by column chromatography eluting with 25% ethyl acetate/petroleum ether (40-60° C.) to give 290 mg of 2-(benzylmethylamino)-5-nitrobenzaldehyde as a yellow oil which solidified on standing; MS: m/e 270.9 [M+H]+.

1. customThe solvent was removed
2. customthe residue was partitioned between water and ethyl acetate (×2)
3. customThe combined organic phases were evaporated
4. customthe residue was purified by column chromatography
5. washeluting with 25% ethyl acetate/petroleum ether (40-60° C.)