反应详情

To LDA prepared at -78° C. in the usual manner was added ethyl isobutyrate (45 g) in THF, and stirred for 1 h. A dry HMPA solution of butyl iodide (107 g) was added, and the mixture was stirred at -78° C. for 1 h and then at room temperature for additional 1 h.

1. stirringthe mixture was stirred at -78° C. for 1 h
2. customat room temperature
3. customfor additional 1 h.