反应详情

(3-Bromopropyl)benzene (20 g) in THF (75 ml) was added dropwise to magnesium (2.43 g) at a rate to maintain gentle reflux. The mixture was stirred for 2 h at RT and oxetane (10 g) was added dropwise. The resulting suspension was stirred at RT for 2 h and at reflux for 16 h and poured into saturated aqueous NH4Cl (100 ml). The mixture was extracted with ER (3×75 ml) and the dried extract was evaporated to leave a yellow oil. Distillation of the oil gave the title compound as a colourless liquid (6.05 g) b.p. 100°-105°/0.4 mmHg. T.l.c. [O] Rf 0.3.

1. temperatureto maintain gentle reflux
2. stirringThe resulting suspension was stirred at RT for 2 h
3. temperatureat reflux for 16 h
4. extractionThe mixture was extracted with ER (3×75 ml)
5. extractionthe dried extract
6. customwas evaporated
7. customto leave a yellow oil
8. distillationDistillation of the oil