Acetone → HCID 13520050, compound

HRID 484747Notes

Reaction equation

HRID 484747 reaction equation
[N:1]1([CH2:6][C:7]([C:9]2[CH:21]=[CH:20][C:19]3[C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH2:12][C:11]=3[CH:10]=2)=O)[CH:5]=[CH:4][N:3]=[CH:2]1.CS(O)(=O)=O.[CH2:27]([SH:30])[CH2:28][SH:29].[OH-].[Na+].CC(C)=O.[ClH:37]>O>[ClH:37].[CH:10]1[C:11]2[CH2:12][C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:19]=2[CH:20]=[CH:21][C:9]=1[C:7]1([CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[S:30][CH2:27][CH2:28][S:29]1

Participants

8

Reactant 6

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 6395Methanesulfonic AcidHCID 109021,2-EthanedithiolHCID 14798Sodium HydroxideHCID 57350Ethanone, 1-(9H-fluoren-2-yl)-2-(1H-imidazol-1-yl)-

Product 1

HCID 13520050HCID 13520050, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 10.0 g. of 2-(1H-imidazol-1-yl)-1-(9H-fluoren-2-yl)ethanone in 25 ml. of methanesulfonic acid were added 12.2 ml. of 1,2-ethanedithiol. After stirring overnight at room temperature, the reaction mixture was poured into water and the solution was made basic with sodium hydroxide. The resulting solid was recovered by filtration and crystallized from acetone/3 equivalents of hydrochloric acid to provide 10.16 g. of the title product, m.p. 248° C.

Workup

  1. filtrationThe resulting solid was recovered by filtration
  2. customto provide 10.16 g

Sources & evidence

ORD record
ord-f9dba5d1a8664328b1b244854326c6f3
Source dataset
uspto-grants-1985_08
Patent number
US04533670

Reaction notes

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