Hydrochloric Acid → HCID 13048313, compound

HRID 484821Notes

Reaction equation

HRID 484821 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=O)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([O-])([O-])=O.[Na+].[Na+].Cl[C:20]([O:22][CH3:23])=[O:21].Cl>[OH-].[Na+]>[CH3:23][O:22][C:20]([NH:1][C@H:2]1[CH2:3][C:4]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:10]1=[O:12])=[O:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6140L-PhenylalanineHCID 6586Methyl chloroformateHCID 10340Sodium Carbonate

Product 1

HCID 13048313HCID 13048313, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To an ice-cooled solution of L-phenylalanine (16.5 g., 0.1 m) in 1N NaOH (100 ml) to which solid Na2CO3 (5.3 g, 0.05 m) had been added was added to the methyl chloroformate (7.8 ml, 0.1 m). Stirring was continued for 1/2 hr. with cooling and 1/2 hr. without. The mixture was carefully acidified with concentrated HCl to pH 2-3. After extraction with CH2Cl2 and drying (Na2SO4), evaporation of the solvent left

Workup

  1. additionhad been added
  2. temperaturewith cooling and 1/2 hr
  3. extractionAfter extraction with CH2Cl2
  4. customdrying
  5. custom(Na2SO4), evaporation of the solvent
  6. waitleft

Sources & evidence

ORD record
ord-f326f5d8b6f34ab0828e6c79bf6e6c87
Source dataset
uspto-grants-1985_08
Patent number
US04533745

Reaction notes

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